Daily Archives: February 10, 2017

Dermatophytic Onychomycosis Therapeutics Market: Global Market Intelligence

Dermatophytic onychomycosis also referred to as ringworm of the nail is one of the most common fungal infections of the nails. This infection results in the change in appearance of the nails such as, increased opaqueness and whitening along with increased thickening and fragility. Tinea unguium specifically describes the dermatophytic invasion of the nail plates and is the most common in cases when an artificial nail is applied as the nails are abraded with the help of an emery board and these boards have a probability of carrying infection and also water collection under the nail results in creation of moist and warm environment favorable for fungal growth. Toenails are more commonly affected than finger nails. Onychomycosis infections accounts for one third of fungal skin infections and the diagnosis can be facilitated with the help of direct microscopy imaging of potassium hydroxide preparation or culture before opting for the treatment of the infection. The occurrence of this infection is more common in the adults aged 50 years and above. 
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This infection can lead to serious health conditions such as it can decrease the peripheral circulation and would result in the conditions such as diabetic foot ulcers, and venous stasis. There are three main classes of organisms that cause onychomycosis namely, dermatophytes (fungi), nondermatophyte molds and yeast. Infection resulting from all these three classes of organisms cause similar symptoms along with similar visual appearance. Dermatophytes such as Microsporum, Epidermophyton and Trichophyton species are the most common dermatophytes responsible for infection and are the most common cause of onychomycosis worldwide. Whereas nondermatophyte molds and yeasts are less common causes of infection accounting for around 2% and 8% of the total onychomycosis infections. 
The five major subtypes of onychomycosis are as follows:
  • White superficial onychomycosis (WSO)

Multiple Myeloma Therapeutics Market: Future Demand & Growth Analysis

Multiple myeloma is a blood disorder related to leukemia and lymphoma, since it generally arises in bone marrow. In multiple myeloma, certain white blood cells (WBCs) begin to proliferate abnormally within the bone marrow. These cells are known as plasma cells. Plasma cells are responsible for manufacturing antibodies in the body that help fight against any infection. In multiple myeloma, excessive plasma cells release abnormal level of proteins in blood and bones. These excess levels of proteins accumulate throughout the body, and result in damaging organs.
The plasma cells while multiplying, create problems inside bones and crowd out healthy blood cells. Chemicals are released by proliferating myeloma plasma cells that result in dissolving bone. Due to this, bones become weak and this is known as lytic lesions. Constant rise in number of these plasma cells in bone marrow, results in spill out from the bone and start depositing in other body part causing organ damage.
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Multiple myeloma majorly affects bone, blood and kidney. Patients suffering from multiple myeloma usually show various symptoms such as bone pain, loss of appetite, fatigue and increased urination. Various tests are performed in order to confirm the disease that includes blood tests, urine tests and bone marrow tests. Blood tests include beta-2 microglobulin level test, complete blood count, serum protein electrophoresis, freelite testing and immunofixation electrophoresis. Urine tests include urine protein electrophoresis and measurement of Bence Jones protein. Bone marrow tests include imaging through different imaging modalities such as X-ray, cytogenetic analysis, and plasma cell labeling index test.
Till date there is no cure for multiple myeloma, however, various treatments are efficient in slowing down the progression of disease. Initial therapy to treat the disease is known as induction therapy. This is followed by stem cell transplantation (SCT). In stem cell transplantation, patient’s stem cells are extracted with the help of machine and are frozen and stored. Then these cells are transplanted into the patient body. Chemotherapy is also performed on the patients that include uptake of various drugs such as Adriamycin, Alkeran, Cytoxan, Oncovin, Pomalyst, Revlimid, Thalomid and Velcade.
The market for multiple myeloma therapeutics is expected to grow with rising incidences of the disease amongst population. The American Cancer Society (ACS) has estimated that by the end of 2014, nearly 24,050 new cases of multiple myeloma will be diagnosed in the U.S. Multiple myeloma is common amongst men than in women and also occurs frequently with increasing age. Hence, rise in geriatric population across the globe will undoubtedly augment the growth of multiple myeloma therapeutics market during the study period. The World Health Organization (WHO) has estimated that by 2050, nearly 2,000 million people will belong to geriatric population.
North America accounted for the largest share by revenue in 2013 of global multiple myeloma therapeutics market. This is due to the fact that majority of the key manufacturers of multiple myeloma therapeutics are based out of North America. Owing to aging population in countries such as Japan, India and China, Asia-Pacific is expected to grow at the fastest CAGR during the period 2014 to 2020. The major players operating in the market include Celgene Corporation and Johnson and Johnson among other significant players.
This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include 
  • North America 

Ethical Pharmaceuticals Market: Emerging Market Trends, Size, Share and Growth Analysis

Ethical pharmaceuticals or prescription drugs are those licensed drugs that are regulated by various legislations to require a written medical prescription before it can be procured. An ethical pharmaceutical product is only sold by a pharmacists when it has been approved by a written medical prescription from a registered medical practitioner. The term prescription drugs or ethical pharmaceutical is usually used to distinguish the products from over-the-counter drugs – drugs that can be obtained without a written medical prescription. However, varied jurisdictions have varied definitions of what constitutes an ethical pharmaceutical. At present, ethical pharmaceuticals, market is highly profitable as well as a risky market venture. The market is expected to be profitable owing to the upcoming patent expiries of many blockbuster drugs; and risky because of the involvement of many established and multinational companies, who have built a global recognition for their safe and effective products.

API Contract Manufacturing Market: Emerging Trends & Upcoming Pharmaceutical Research

Active pharmaceutical ingredients (APIs) are also referred as ‘bulk pharmaceuticals’ and they are the base of the pharmaceutical industry. APIs are used in the manufacture of various pharmaceutical and drug products, intended to yield the desired pharmacological effect. APIs are produced through various processes such as chemical synthesis, fermentation process, isolation etc. Active pharmaceutical ingredient contract manufacturing market is one of the fastest growing markets of the pharmaceutical industry. Owing to the increasing number of contract manufacturing organizations (CMOs), the process of active pharmaceutical ingredient manufacturing is now being outsourced in order to reduce cost and increase product quality. Most of the pharmaceutical companies are increasingly concentrating on R&D and marketing activities, and therefore shifting their focus from non-core activities to the above core activities. The API contract manufacturing market is segmented as follows:

Premenstrual Syndrome Market: Future Demand and Growth Analysis

Premenstrual syndrome (PMS) alternatively known as premenstrual tension is a combination of physical, emotional, psychological disturbances among women of child bearing age. Premenstrual syndrome symptom occurs 1-2 weeks before the onset of menstruation and usually disappears once the menstrual bleeding starts. The exact cause of the disease is though not clear yet fluctuations in hormone level are one of the prominent reasons for onset of symptoms. 
Other associated cause of the disease include low level of vitamin and mineral level, high intake of salty food and frequent alcohol & caffeine consumption. Symptoms of the diseases include acne, swollen breasts, troubled sleeping, muscles pain, mood swings and anxiety disorders. A more severe form of PMS known as premenstrual dysphoric disorder, characterized by repeated transitory cyclic disorder along with increased level of anger, anxiety and tension as compared to PMS disease. 
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Approximately 20-30% of the menstruating women are believed to be affected by premenstrual syndrome of which 3-8% of them have premenstrual dysphoric disorder. Drugs that are usually employed as therapeutics include nonsteroidal anti-inflammatory drugs which control and regulate symptoms such as abdominal cramps, joint pain and headache. Antidepressants such as fluoxetine, paroxetine and sertraline can also be included in the regular therapy but it must be taken before actual symptoms begin. In premenstrual dysphoric disorder, gonadotropin-releasing hormone (GnRH) agonists such as leuprolide or goserelin can also be employed to regulate rapid fluctuations in the hormone levels. 
Nutritional therapy such as vitamin B6, vitamin E, calcium and magnesium along with moderate exercise help in increasing success rate of treatment. Calcium carbonate can be recommended as first-line therapy for women with mild-to-moderate PMS whereas, selective serotonin reuptake inhibitors can be considered as first-line therapy for women with severe PMS complications.
Major drivers to the growth of premenstrual syndrome market includes increasing inclination of key players and government interventions towards developing novel therapeutics as a long term cure to this disease. Awareness and growing concern about premenstrual syndrome especially among women from developed economic countries have effectively contributed towards demand for PMS drugs and diagnostic tests. Till date there is no diagnostic device present to confirm PMS or PMDD yet two of the well-validated scales for the recording of premenstrual symptoms include the Calendar of Premenstrual Experiences (COPE) and the Prospective Record of the Severity of Menstruation (PRISM). Growing demand for hormone therapy based treatment across the globe has tremendously contributed towards increase in revenues and upliftment of PMS market. 
Geographically, North America and Europe market are major contributors in terms of revenues and research activities. Availability of advanced diagnostic equipments and healthcare facilities has a major contribution towards growth and development of market in past few years. Rest of the World and Asia-Pacific market are among the most lucrative market for existing as well as new players in forthcoming years owing to large women population base and increasing incidences of lifestyle related disorders in past one decade. Government interventions and campaigns with respect to women health and well-being are effectively contributing towards increasing awareness about Premenstrual syndrome and other associated menstrual disorders in developing economic countries. Some of the pipelined drugs in the market include ProgestoMat, Cis-platinum, CDB-2914, PH80-PMD, Dutasteride and others. 
Some of the key players operating in the Premenstrual Syndrome market include MetP Pharma AG, Umecrine Mood AB, DEKK-TEC, Inc., Pherin Pharmaceuticals, Inc. and others. 
This research report analyzes this market on the basis of its market segments, major geographies, and current market trends. Geographies analyzed under this research report include 
  • North America 

Global Biologics Market: Highly Profitable Returns through Premium Prices to Drive Increased Investments

The global market for biologics features a fragmented competitive landscape with stakeholders being some of the world’s most influential pharmaceutical companies and several domestic companies, which are vying for a share in the highly profitable market, observes Transparency Market Research (TMR) in a recent report. “A popular trend in the market is strategic mergers and acquisitions, with big companies wanting to expand their services and manufacturing units globally and enhancing product portfolios by co-development activities and licensing deals,” states a TMR analyst.

Global Radiopharmaceutical Market: Rise in Demand for Diagnostic Procedures and Devices Bolsters Need for Radioisotopes, finds TMR

The radiopharmaceutical market is highly consolidated, wherein the top two players – Siemens Healthineers and GE Healthcare – jointly accounted for over 70% of the global market in 2015. Transparency Market Research has observed that the degree of competition is rather high in the market owing to the presence of key players with the availability of advanced technologies and potential productive sources and a high product manufacturing capacity.

U.S. and China Asthma and COPD Drugs Market: Future Demand and Growth Analysis

The top five companies in the U.S. and China asthma and COPD drugs market accounted for just under 64.0% in 2015, hinting at not just the consolidated nature of this industry but also at the immense competition among players. GlaxoSmithKline plc, Astrazeneca plc, Boehringer Ingelheim, Merck & Co. Inc., and Novartis AG currently enjoy the leading spots in the asthma and COPD drugs market.

According to Transparency Market Research, the opportunity in the U.S. and China asthma and COPD drugs market is slated to rise from a valuation of US$13.0 bn in 2015 to be worth US$18.7 bn by 2024. If these values hold true, the market is likely to expand at a modest CAGR of 4.1% therein.

Global Bovine Respiratory Disease Treatment Market: Valuation to Nearly Double by 2024, predicts TMR

The global market for bovine respiratory disease treatment features a highly consolidated competitive landscape despite the presence of a large number of regional players, observes a recent report by Transparency Market Research. Owing to the small duration of product exclusivity in the animal health care industry – about three to five years – competition from generics and over-the-counter (OTC) products is a big threat.

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